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Transgenic knockout mice exclusively expressing human hemoglobin S after transfer of a 240-kb β(s)-globin yeast artificial chromosome: A mouse model of sickle cell anemia

Sickle cell anemia (SCA) and thalassemia are among the most common genetic diseases worldwide. Current approaches to the development of murine models of SCA involve the elimination of functional murine α- and β-globin genes and substitution with human α and β(s) transgenes. Recently, two groups have...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Chang, Judy C., Lu, Ronghua, Lin, Chin, Xu, Shan-Mei, Kan, Yuet Wai, Porcu, Susanna, Carlson, Elaine, Kitamura, Michael, Yang, Suya, Flebbe-Rehwaldt, Linda, Gaensler, Karin M. L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24545/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9843985/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.25.14886
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