Transgenic knockout mice exclusively expressing human hemoglobin S after transfer of a 240-kb β(s)-globin yeast artificial chromosome: A mouse model of sickle cell anemia

Sickle cell anemia (SCA) and thalassemia are among the most common genetic diseases worldwide. Current approaches to the development of murine models of SCA involve the elimination of functional murine α- and β-globin genes and substitution with human α and β(s) transgenes. Recently, two groups have...

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Main Authors: Chang, Judy C., Lu, Ronghua, Lin, Chin, Xu, Shan-Mei, Kan, Yuet Wai, Porcu, Susanna, Carlson, Elaine, Kitamura, Michael, Yang, Suya, Flebbe-Rehwaldt, Linda, Gaensler, Karin M. L.
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 1998
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC24545/
https://ncbi.nlm.nih.gov/pubmed/9843985
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