Transgenic knockout mice exclusively expressing human hemoglobin S after transfer of a 240-kb β(s)-globin yeast artificial chromosome: A mouse model of sickle cell anemia

Sickle cell anemia (SCA) and thalassemia are among the most common genetic diseases worldwide. Current approaches to the development of murine models of SCA involve the elimination of functional murine α- and β-globin genes and substitution with human α and β(s) transgenes. Recently, two groups have...

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Main Authors: Chang, Judy C., Lu, Ronghua, Lin, Chin, Xu, Shan-Mei, Kan, Yuet Wai, Porcu, Susanna, Carlson, Elaine, Kitamura, Michael, Yang, Suya, Flebbe-Rehwaldt, Linda, Gaensler, Karin M. L.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1998
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC24545/
https://ncbi.nlm.nih.gov/pubmed/9843985
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