Disruption of Tsc2 in pancreatic β cells induces β cell mass expansion and improved glucose tolerance in a TORC1-dependent manner

Regulation of pancreatic β cell mass and function is a major determinant for the development of diabetes. Growth factors and nutrients are important regulators of β cell mass and function. The signaling pathways by which these growth signals modulate these processes have not been completely elucidat...

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Main Authors: Rachdi, Latif, Balcazar, Norman, Osorio-Duque, Fernando, Elghazi, Lynda, Weiss, Aaron, Gould, Aaron, Chang-Chen, Karen J., Gambello, Michael J., Bernal-Mizrachi, Ernesto
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453727/
https://ncbi.nlm.nih.gov/pubmed/18587048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803047105
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