Decreased IRS Signaling Impairs β-Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in β-Cells

OBJECTIVE: The purpose of this study was to evaluate the role of the S6K arm of mammalian target of rapamycin complex 1 (mTORC1) signaling in regulation of β-cell mass and function. Additionally, we aimed to delineate the importance of in vivo S6K activation in the regulation of insulin signaling an...

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Главные авторы: Elghazi, Lynda, Balcazar, Norman, Blandino-Rosano, Manuel, Cras-Méneur, Corentin, Fatrai, Szabolcs, Gould, Aaron P., Chi, Maggie M., Moley, Kelle H., Bernal-Mizrachi, Ernesto
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2010
Предметы:
Metabolism
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279560/
https://ncbi.nlm.nih.gov/pubmed/20622167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0851
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