mTORC1 Activation Regulates β-Cell Mass and Proliferation by Modulation of Cyclin D2 Synthesis and Stability

Growth factors, insulin signaling, and nutrients are important regulators of β-cell mass and function. The events linking these signals to the regulation of β-cell mass are not completely understood. The mTOR pathway integrates signals from growth factors and nutrients. Here, we evaluated the role o...

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Autors principals: Balcazar, Norman, Sathyamurthy, Aruna, Elghazi, Lynda, Gould, Aaron, Weiss, Aaron, Shiojima, Ichiro, Walsh, Kenneth, Bernal-Mizrachi, Ernesto
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Protein Synthesis, Post-Translational Modification, and Degradation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658077/
https://ncbi.nlm.nih.gov/pubmed/19144649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807458200
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