Liquid-crystal NMR structure of HIV TAR RNA bound to its SELEX RNA aptamer reveals the origins of the high stability of the complex

Transactivation-response element (TAR) is a stable stem–loop structure of HIV RNA, which plays a crucial role during the life cycle of the virus. The apical loop of TAR acts as a binding site for essential cellular cofactors required for the replication of HIV. High-affinity aptamers directed agains...

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Bibliographic Details
Main Authors: Van Melckebeke, Hélène, Devany, Matthew, Di Primo, Carmelo, Beaurain, François, Toulmé, Jean-Jacques, Bryce, David L., Boisbouvier, Jérôme
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453701/
https://ncbi.nlm.nih.gov/pubmed/18607001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712121105
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