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The relationship between dNTP pool levels and mutagenesis in an Escherichia coli NDP kinase mutant

Loss of nucleoside diphosphate kinase (Ndk) function in Escherichia coli results in an increased frequency of spontaneous mutation and an imbalance in dNTP pool levels. It is presumed that the imbalance in dNTP pool levels is responsible for the mutator phenotype of an E. coli ndk mutant. A human ho...

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Autors principals: Nordman, Jared, Wright, Andrew
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453072/
https://ncbi.nlm.nih.gov/pubmed/18621712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802816105
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