The antibody catalysis route to the total synthesis of epothilones
An efficient monoclonal aldolase antibody that proceeds by an enamine mechanism was generated by reactive immunization. Here, this catalyst has been used in the total synthesis of epothilones A (1) and C (3). The starting materials for the synthesis of these molecules have been obtained by using ant...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24496/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9843936/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.25.14603 |
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