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Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2
In addition to its role in megakaryocyte production, signaling initiated by thrombopoietin (TPO) activation of its receptor, myeloproliferative leukemia virus protooncogene (c-Mpl, or Mpl), controls HSC homeostasis and self-renewal. Under steady-state conditions, mice lacking the inhibitory adaptor...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2447929/ https://ncbi.nlm.nih.gov/pubmed/18618018 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35808 |
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