SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing

The survival of motor neurons protein (SMN) is essential for the biogenesis of small nuclear RNA (snRNA)-ribonucleoproteins (snRNPs), the major components of the pre-mRNA splicing machinery. Though it is ubiquitously expressed, SMN deficiency causes the most common motor neuron degenerative disease,...

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Hlavní autoři: Zhang, Zhenxi, Lotti, Francesco, Dittmar, Kimberly, Younis, Ihab, Wan, Lili, Kasim, Mumtaz, Dreyfuss, Gideon
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2446403/
https://ncbi.nlm.nih.gov/pubmed/18485868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.03.031
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