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SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing
The survival of motor neurons protein (SMN) is essential for the biogenesis of small nuclear RNA (snRNA)-ribonucleoproteins (snRNPs), the major components of the pre-mRNA splicing machinery. Though it is ubiquitously expressed, SMN deficiency causes the most common motor neuron degenerative disease,...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2446403/ https://ncbi.nlm.nih.gov/pubmed/18485868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.03.031 |
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