Prion Protein Complexed to N2a Cellular RNAs through Its N-terminal Domain Forms Aggregates and Is Toxic to Murine Neuroblastoma Cells

Conversion of the cellular prion protein (PrP(C)) into its altered conformation, PrP(Sc), is believed to be the major cause of prion diseases. Although PrP is the only identified agent for these diseases, there is increasing evidence that other molecules can modulate the conversion. We have found th...

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Main Authors: Gomes, Mariana P. B., Millen, Thiago A., Ferreira, Priscila S., e Silva, Narcisa L. Cunha, Vieira, Tuane C. R. G., Almeida, Marcius S., Silva, Jerson L., Cordeiro, Yraima
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2008
נושאים:
Protein Structure and Folding
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443653/
https://ncbi.nlm.nih.gov/pubmed/18456654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802102200
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