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Heparin binding confers prion stability and impairs its aggregation
The conversion of the prion protein (PrP) into scrapie PrP (PrP(Sc)) is a central event in prion diseases. Several molecules work as cofactors in the conversion process, including glycosaminoglycans (GAGs). GAGs exhibit a paradoxical effect, as they convert PrP into protease-resistant PrP (PrP-res)...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Federation of American Societies for Experimental Biology
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4021443/ https://ncbi.nlm.nih.gov/pubmed/24648544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-246777 |
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