Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

The correlation between telomerase activity and human tumors has led to the hypothesis that tumor growth requires reactivation of telomerase and that telomerase inhibitors represent a class of chemotherapeutic agents. Herein, we examine the effects of inhibition of telomerase inside human cells. Pep...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Herbert, B.-S., Pitts, A. E., Baker, S. I., Hamilton, S. E., Wright, W. E., Shay, J. W., Corey, D. R.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1999
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24427/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10588696/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.25.14276
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