Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

The correlation between telomerase activity and human tumors has led to the hypothesis that tumor growth requires reactivation of telomerase and that telomerase inhibitors represent a class of chemotherapeutic agents. Herein, we examine the effects of inhibition of telomerase inside human cells. Pep...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Herbert, B.-S., Pitts, A. E., Baker, S. I., Hamilton, S. E., Wright, W. E., Shay, J. W., Corey, D. R.
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1999
Fag:	Biological Sciences
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24427/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10588696/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.25.14276
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