Treatment with DF 2162, a non-competitive allosteric inhibitor of CXCR1/2, diminishes neutrophil influx and inflammatory hypernociception in mice

BACKGROUND AND PURPOSE: Neutrophil migration into tissues is involved in the genesis of inflammatory pain. Here, we addressed the hypothesis that the effect of CXC chemokines on CXCR1/2 is important to induce neutrophil migration and inflammatory hypernociception. EXPERIMENTAL APPROACH: Mice were tr...

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Autors principals: Cunha, T M, Barsante, M M, Guerrero, A T, Verri, W A, Ferreira, S H, Coelho, F M, Bertini, R, Di Giacinto, C, Allegretti, M, Cunha, F Q, Teixeira, M M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2008
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442455/
https://ncbi.nlm.nih.gov/pubmed/18362895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.94
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