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Specific mutations in a viral RNA pseudoknot drastically change ribosomal frameshifting efficiency

Many viruses regulate protein synthesis by −1 ribosomal frameshifting using an RNA pseudoknot. Frameshifting is vital for viral reproduction. Using the information gained from the recent high-resolution crystal structure of the beet western yellow virus pseudoknot, a systematic mutational analysis h...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kim, Yang-Gyun, Su, Li, Maas, Stefan, O’Neill, Analeah, Rich, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24420/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10588689/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.25.14234
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