In vivo gene repair of point and frameshift mutations directed by chimeric RNA/DNA oligonucleotides and modified single-stranded oligonucleotides

Synthetic oligonucleotides have been used to direct base exchange and gene repair in a variety of organisms. Among the most promising vectors is chimeric oligonucleotide (CO), a double-stranded, RNA–DNA hybrid molecule folded into a double hairpin conformation: by using the cell’s DNA repair machine...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Liu, Li, Rice, Michael C., Kmiec, Eric B.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC60207/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11600713/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.20.4238
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