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Perturbation of the tRNA Tertiary Core Differentially Affects Specific Steps of the Elongation Cycle

The tRNA tertiary core region is important for both tRNA stability and activity in the translation elongation cycle. Here we report the effects of mutating each of two highly conserved base pairs in the tertiary core of Phe-tRNA(Phe), 18-55 and 19-56, on rate and equilibrium constants for specific s...

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Detalhes bibliográficos
Main Authors: Pan, Dongli, Zhang, Chun-Mei, Kirillov, Stanislav, Hou, Ya-Ming, Cooperman, Barry S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440604/
https://ncbi.nlm.nih.gov/pubmed/18448426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801560200
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