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Defects in Transient tRNA Translocation Bypass tRNA Synthetase Quality Control Mechanisms
Quality control mechanisms during protein synthesis are essential to fidelity and cell survival. Leucyl-tRNA synthetase (LeuRS) misactivates non-leucine amino acids including isoleucine, methionine, and norvaline. To prevent translational errors, mischarged tRNA products are translocated 30Å from th...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2670153/ https://ncbi.nlm.nih.gov/pubmed/19258309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807395200 |
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