Yeast Mitochondrial Leucyl-tRNA Synthetase CP1 Domain Has Functionally Diverged to Accommodate RNA Splicing at Expense of Hydrolytic Editing

The yeast mitochondrial leucyl-tRNA synthetase (ymLeuRS) performs dual essential roles in group I intron splicing and protein synthesis. A specific LeuRS domain called CP1 is responsible for clearing noncognate amino acids that are misactivated during aminoacylation. The ymLeuRS CP1 domain also play...

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Autori principali: Sarkar, Jaya, Poruri, Kiranmai, Boniecki, Michal T., McTavish, Katherine K., Martinis, Susan A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
Soggetti:
Protein Synthesis and Degradation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340235/
https://ncbi.nlm.nih.gov/pubmed/22383526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.322412
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