Defects in Transient tRNA Translocation Bypass tRNA Synthetase Quality Control Mechanisms

Quality control mechanisms during protein synthesis are essential to fidelity and cell survival. Leucyl-tRNA synthetase (LeuRS) misactivates non-leucine amino acids including isoleucine, methionine, and norvaline. To prevent translational errors, mischarged tRNA products are translocated 30Å from th...

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Bibliographische Detailangaben
Hauptverfasser: Hellmann, Rachel A., Martinis, Susan A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670153/
https://ncbi.nlm.nih.gov/pubmed/19258309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807395200
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