Efficient and accurate bypass of N(2)-(1-carboxyethyl)-2′-deoxyguanosine by DinB DNA polymerase in vitro and in vivo

DinB, a Y-family DNA polymerase, is conserved among all domains of life; however, its endogenous substrates have not been identified. DinB is known to synthesize accurately across a number of N(2)-dG lesions. Methylglyoxal (MG) is a common byproduct of the ubiquitous glycolysis pathway and induces t...

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Bibliographic Details
Main Authors: Yuan, Bifeng, Cao, Huachuan, Jiang, Yong, Hong, Haizheng, Wang, Yinsheng
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2438377/
https://ncbi.nlm.nih.gov/pubmed/18562283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711546105
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