Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs

Mechanisms to safely eliminate amyloids and preamyloid oligomers associated with many devastating diseases are urgently needed. Biophysical principles dictate that small molecules are unlikely to perturb large intermolecular protein–protein interfaces, let alone extraordinarily stable amyloid interf...

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Autori principali: Wang, Huan, Duennwald, Martin L., Roberts, Blake E., Rozeboom, Leslie M., Zhang, Yingxin L., Steele, Andrew D., Krishnan, Rajaraman, Su, Linhui Julie, Griffin, Drees, Mukhopadhyay, Samrat, Hennessy, Edward J., Weigele, Peter, Blanchard, Barbara J., King, Jonathan, Deniz, Ashok A., Buchwald, Stephen L., Ingram, Vernon M., Lindquist, Susan, Shorter, James
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2438221/
https://ncbi.nlm.nih.gov/pubmed/18480256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801934105
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