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Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule
The Aβ1-42 peptide that is overproduced in Alzheimer's disease (AD) from a large precursor protein has a normal amino acid sequence but, when liberated, misfolds at neutral pH to form “protofibrils” and fibrils that are rich in β-sheets. We find that these protofibrils or fibrils are toxic to c...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC521943/ https://ncbi.nlm.nih.gov/pubmed/15388848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405941101 |
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