Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs

Mechanisms to safely eliminate amyloids and preamyloid oligomers associated with many devastating diseases are urgently needed. Biophysical principles dictate that small molecules are unlikely to perturb large intermolecular protein–protein interfaces, let alone extraordinarily stable amyloid interf...

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Autors principals: Wang, Huan, Duennwald, Martin L., Roberts, Blake E., Rozeboom, Leslie M., Zhang, Yingxin L., Steele, Andrew D., Krishnan, Rajaraman, Su, Linhui Julie, Griffin, Drees, Mukhopadhyay, Samrat, Hennessy, Edward J., Weigele, Peter, Blanchard, Barbara J., King, Jonathan, Deniz, Ashok A., Buchwald, Stephen L., Ingram, Vernon M., Lindquist, Susan, Shorter, James
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2438221/
https://ncbi.nlm.nih.gov/pubmed/18480256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801934105
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