Ribosome display efficiently selects and evolves high-affinity antibodies in vitro from immune libraries

Ribosome display was applied for affinity selection of antibody single-chain fragments (scFv) from a diverse library generated from mice immunized with a variant peptide of the transcription factor GCN4 dimerization domain. After three rounds of ribosome display, positive scFvs were isolated and cha...

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Detaylı Bibliyografya
Asıl Yazarlar: Hanes, Jozef, Jermutus, Lutz, Weber-Bornhauser, Susanne, Bosshard, Hans Rudolf, Plückthun, Andreas
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 1998
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC24338/
https://ncbi.nlm.nih.gov/pubmed/9826665
Etiketler: Etiketle
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