Ribosome display efficiently selects and evolves high-affinity antibodies in vitro from immune libraries
Ribosome display was applied for affinity selection of antibody single-chain fragments (scFv) from a diverse library generated from mice immunized with a variant peptide of the transcription factor GCN4 dimerization domain. After three rounds of ribosome display, positive scFvs were isolated and cha...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24338/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9826665/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.24.14130 |
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