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Cognizance of Molecular Methods for the Generation of Mutagenic Phage Display Antibody Libraries for Affinity Maturation

Antibodies leverage on their unique architecture to bind with an array of antigens. The strength of interaction has a direct relation to the affinity of the antibodies towards the antigen. In vivo affinity maturation is performed through multiple rounds of somatic hypermutation and selection in the...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Lim, Chia Chiu, Choong, Yee Siew, Lim, Theam Soon
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6515083/
https://ncbi.nlm.nih.gov/pubmed/30991723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20081861
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