Phosphoinositide Binding to the Substrate Regulates Susceptibility to Proteolysis by Calpain

Calpain-mediated proteolysis regulates cytoskeletal dynamics and is altered during aging and the progression of numerous diseases or pathological conditions. Although several cytoskeletal proteins have been identified as substrates, how localized calpain activity is regulated and the mechanisms cont...

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Hlavní autoři: Sprague, Chelsea R., Fraley, Tamara S., Jang, Hyo Sang, Lal, Sangeet, Greenwood, Jeffrey A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Protein Synthesis, Post-Translational Modification, and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431029/
https://ncbi.nlm.nih.gov/pubmed/18258589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707436200
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