Phosphoinositide Binding to the Substrate Regulates Susceptibility to Proteolysis by Calpain

Calpain-mediated proteolysis regulates cytoskeletal dynamics and is altered during aging and the progression of numerous diseases or pathological conditions. Although several cytoskeletal proteins have been identified as substrates, how localized calpain activity is regulated and the mechanisms cont...

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Bibliographische Detailangaben
Hauptverfasser: Sprague, Chelsea R., Fraley, Tamara S., Jang, Hyo Sang, Lal, Sangeet, Greenwood, Jeffrey A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2008
Schlagworte:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431029/
https://ncbi.nlm.nih.gov/pubmed/18258589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707436200
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