Ubiquitylation on Canonical and Non-canonical Sites Targets the Transcription Factor Neurogenin for Ubiquitin-mediated Proteolysis

Polyubiquitylation targets multiple proteins for degradation by the proteasome. Typically, the first ubiquitin is linked to lysine residues in the substrate for degradation via an isopeptide bond, although rarely ubiquitin linkage to the N-terminal residue has also been observed. We have recently sh...

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Detalhes bibliográficos
Main Authors: Vosper, Jonathan M. D., McDowell, Gary S., Hindley, Christopher J., Fiore-Heriche, Christelle S., Kucerova, Romana, Horan, Ian, Philpott, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708843/
https://ncbi.nlm.nih.gov/pubmed/19336407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M809366200
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