Estrogen Receptor-α variants increase risk of Alzheimer’s Disease in women with Down syndrome

BACKGROUND: Genetic variants that affect estrogen activity may influence the risk of Alzheimer’s disease (AD). Two tightly linked polymorphisms (PvuII and XbaI) in the first intron of estrogen receptor 1 (ESR1), the gene for ER-α, have been reported to influence estrogen receptor expression and may...

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Autori principali: Schupf, Nicole, Lee, Joseph. H., Wei, Michelle, Pang, Deborah, Chace, Constance, Rong, Cheng, Zigman, Warren B., Tycko, Benjamin, Silverman, Wayne
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430887/
https://ncbi.nlm.nih.gov/pubmed/18408366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000126495
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