CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation

Runx2, an essential transactivator for osteoblast differentiation, is tightly regulated at both the transcriptional and posttranslational levels. In this paper, we report that CHIP (C terminus of Hsc70-interacting protein)/STUB1 regulates Runx2 protein stability via a ubiquitination-degradation mech...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Li, Xueni, Huang, Mei, Zheng, Huiling, Wang, Yinyin, Ren, Fangli, Shang, Yu, Zhai, Yonggong, Irwin, David M., Shi, Yuguang, Chen, Di, Chang, Zhijie
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2426947/
https://ncbi.nlm.nih.gov/pubmed/18541707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200711044
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados