CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation

Runx2, an essential transactivator for osteoblast differentiation, is tightly regulated at both the transcriptional and posttranslational levels. In this paper, we report that CHIP (C terminus of Hsc70-interacting protein)/STUB1 regulates Runx2 protein stability via a ubiquitination-degradation mech...

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Autori principali: Li, Xueni, Huang, Mei, Zheng, Huiling, Wang, Yinyin, Ren, Fangli, Shang, Yu, Zhai, Yonggong, Irwin, David M., Shi, Yuguang, Chen, Di, Chang, Zhijie
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2008
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2426947/
https://ncbi.nlm.nih.gov/pubmed/18541707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200711044
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