CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation

Runx2, an essential transactivator for osteoblast differentiation, is tightly regulated at both the transcriptional and posttranslational levels. In this paper, we report that CHIP (C terminus of Hsc70-interacting protein)/STUB1 regulates Runx2 protein stability via a ubiquitination-degradation mech...

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Bibliographic Details
Main Authors: Li, Xueni, Huang, Mei, Zheng, Huiling, Wang, Yinyin, Ren, Fangli, Shang, Yu, Zhai, Yonggong, Irwin, David M., Shi, Yuguang, Chen, Di, Chang, Zhijie
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2008
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2426947/
https://ncbi.nlm.nih.gov/pubmed/18541707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200711044
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