E3 Ubiquitin Ligase Fbw7 Negatively Regulates Osteoblast Differentiation by Targeting Runx2 for Degradation

Runx2, a master regulator of osteoblast differentiation, is tightly regulated at both transcriptional and post-translational levels. Post-translational modifications such as phosphorylation and ubiquitination have differential effects on Runx2 functions. Here, we show that the reduced expression and...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kumar, Yogesh, Kapoor, Isha, Khan, Kainat, Thacker, Gatha, Khan, Mohd. Parvez, Shukla, Nidhi, Kanaujiya, Jitendra Kumar, Sanyal, Sabyasachi, Chattopadhyay, Naibedya, Trivedi, Arun Kumar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692224/
https://ncbi.nlm.nih.gov/pubmed/26542806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.669531
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