Effects on Membrane Capacitance of Steroids with Antagonist Properties at GABA(A) Receptors

We investigated the electrophysiological signature of neuroactive steroid interactions with the plasma membrane. We found that charged, sulfated neuroactive steroids, those that exhibit noncompetitive antagonism of GABA(A) receptors, altered capacitive charge movement in response to voltage pulses i...

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Bibliographic Details
Main Authors: Mennerick, Steven, Lamberta, Michael, Shu, Hong-Jin, Hogins, Joshua, Wang, Cunde, Covey, Douglas F., Eisenman, Lawrence N., Zorumski, Charles F.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2008
Subjects:
Channels, Receptors, and Electrical Signaling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2426621/
https://ncbi.nlm.nih.gov/pubmed/18339741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.124768
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