Effects on Membrane Capacitance of Steroids with Antagonist Properties at GABA(A) Receptors

We investigated the electrophysiological signature of neuroactive steroid interactions with the plasma membrane. We found that charged, sulfated neuroactive steroids, those that exhibit noncompetitive antagonism of GABA(A) receptors, altered capacitive charge movement in response to voltage pulses i...

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Autors principals: Mennerick, Steven, Lamberta, Michael, Shu, Hong-Jin, Hogins, Joshua, Wang, Cunde, Covey, Douglas F., Eisenman, Lawrence N., Zorumski, Charles F.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2008
Matèries:
Channels, Receptors, and Electrical Signaling
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2426621/
https://ncbi.nlm.nih.gov/pubmed/18339741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.124768
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