The Influence of Neuroactive Steroid Lipophilicity on GABA(A) Receptor Modulation: Evidence for a Low-Affinity Interaction

Anesthetic steroids with actions at γ-aminobutyric acid type A receptors (GABA(A)Rs) may access transmembrane domain binding site(s) directly from the plasma cell membrane. Accordingly, the effective concentration in lipid phase and the ability of the steroid to meet pharmacophore requirements for a...

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Main Authors: Chisari, Mariangela, Eisenman, Lawrence N., Krishnan, Kathiresan, Bandyopadhyaya, Achintya K., Wang, Cunde, Taylor, Amanda, Benz, Ann, Covey, Douglas F., Zorumski, Charles F., Mennerick, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724350/
https://ncbi.nlm.nih.gov/pubmed/19553485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00346.2009
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