3β-Hydroxypregnane Steroids Are Pregnenolone Sulfate-Like GABA(A) Receptor Antagonists

Endogenous neurosteroids have rapid actions on ion channels, particularly GABA(A) receptors, which are potentiated by nanomolar concentrations of 3α-hydroxypregnane neurosteroids. Previous evidence suggests that 3β-hydroxypregnane steroids may competitively antagonize potentiation induced by their 3...

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Pubblicato in:J Neurosci
Autori principali: Wang, Mingde, He, Yejun, Eisenman, Lawrence N., Fields, Christopher, Zeng, Chun-Min, Mathews, Jose, Benz, Ann, Fu, Tao, Zorumski, Erik, Steinbach, Joe Henry, Covey, Douglas F., Zorumski, Charles F., Mennerick, Steven
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758359/
https://ncbi.nlm.nih.gov/pubmed/11978813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-09-03366.2002
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