The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation

Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial and apparently sporadic Parkinson disease. LRRK2 is a multidomain protein kinase with autophosphorylation activity. It has previously been shown that the kinase activity of LRRK2 is required for neuronal toxicity, sugge...

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Bibliographic Details
Main Authors: Greggio, Elisa, Zambrano, Ibardo, Kaganovich, Alice, Beilina, Alexandra, Taymans, Jean-Marc, Daniëls, Veronique, Lewis, Patrick, Jain, Shushant, Ding, Jinhui, Syed, Ali, Thomas, Kelly J., Baekelandt, Veerle, Cookson, Mark R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423262/
https://ncbi.nlm.nih.gov/pubmed/18397888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708718200
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