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Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1,N(6)-ethenoadenine and hypoxanthine but not of 3,N(4)-ethenocytosine or 8-oxoguanine
It has previously been reported that 1,N(6)-ethenoadenine (ɛA), deaminated adenine (hypoxanthine, Hx), and 7,8-dihydro-8-oxoguanine (8-oxoG), but not 3,N(4)-ethenocytosine (ɛC), are released from DNA in vitro by the DNA repair enzyme alkylpurine-DNA-N-glycosylase (APNG). To assess the potential cont...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences of the USA
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC24230/ https://ncbi.nlm.nih.gov/pubmed/9371767 |
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