Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1,N(6)-ethenoadenine and hypoxanthine but not of 3,N(4)-ethenocytosine or 8-oxoguanine
It has previously been reported that 1,N(6)-ethenoadenine (ɛA), deaminated adenine (hypoxanthine, Hx), and 7,8-dihydro-8-oxoguanine (8-oxoG), but not 3,N(4)-ethenocytosine (ɛC), are released from DNA in vitro by the DNA repair enzyme alkylpurine-DNA-N-glycosylase (APNG). To assess the potential cont...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24230/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9371767/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.24.12869 |
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