Alkylpurine–DNA–N-Glycosylase Knockout Mice Show Increased Susceptibility to Induction of Mutations by Methyl Methanesulfonate

Alkylpurine-DNA-N-glycosylase (APNG) null mice have been generated by homologous recombination in embryonic stem cells. The null status of the animals was confirmed at the mRNA level by reverse transcription-PCR and by the inability of cell extracts of tissues from the knockout (ko) animals to relea...

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Autors principals: Elder, Rhoderick H., Jansen, Jacob G., Weeks, Robert J., Willington, Mark A., Deans, Bryan, Watson, Amanda J., Mynett, Kurt J., Bailey, John A., Cooper, Donald P., Rafferty, Joseph A., Heeran, Mel C., Wijnhoven, Susan W. P., van Zeeland, Albert A., Margison, Geoffrey P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1998
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC109169/
https://ncbi.nlm.nih.gov/pubmed/9742100
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