Alkylpurine–DNA–N-Glycosylase Knockout Mice Show Increased Susceptibility to Induction of Mutations by Methyl Methanesulfonate

Alkylpurine-DNA-N-glycosylase (APNG) null mice have been generated by homologous recombination in embryonic stem cells. The null status of the animals was confirmed at the mRNA level by reverse transcription-PCR and by the inability of cell extracts of tissues from the knockout (ko) animals to relea...

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Autori principali: Elder, Rhoderick H., Jansen, Jacob G., Weeks, Robert J., Willington, Mark A., Deans, Bryan, Watson, Amanda J., Mynett, Kurt J., Bailey, John A., Cooper, Donald P., Rafferty, Joseph A., Heeran, Mel C., Wijnhoven, Susan W. P., van Zeeland, Albert A., Margison, Geoffrey P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 1998
Soggetti:
Cell Growth and Development
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC109169/
https://ncbi.nlm.nih.gov/pubmed/9742100
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