A synthetic host-guest system achieves avidin-biotin affinity by overcoming enthalpy–entropy compensation

The molecular host cucurbit[7]uril forms an extremely stable inclusion complex with the dicationic ferrocene derivative bis(trimethylammoniomethyl)ferrocene in aqueous solution. The equilibrium association constant for this host-guest pair is 3 × 10(15) M(−1) (K(d) = 3 × 10(−16) M), equivalent to th...

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Bibliographic Details
Main Authors: Rekharsky, Mikhail V., Mori, Tadashi, Yang, Cheng, Ko, Young Ho, Selvapalam, N., Kim, Hyunuk, Sobransingh, David, Kaifer, Angel E., Liu, Simin, Isaacs, Lyle, Chen, Wei, Moghaddam, Sarvin, Gilson, Michael K., Kim, Kimoon, Inoue, Yoshihisa
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2410071/
https://ncbi.nlm.nih.gov/pubmed/18093926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706407105
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