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New ultra-high affinity host-guest complexes of cucurbit[7]uril with bicyclo[2.2.2]octane and adamantane guests: Thermodynamic analysis and evaluation of M2 affinity calculations

A dicationic ferrocene derivative has previously been shown to bind cucurbit[7]uril (CB[7]) in water with ultra-high affinity (ΔG(o)= −21 kcal/mol). Here, we describe new compounds that bind aqueous CB[7] equally well, validating our prior suggestion that they, too, would be ultra-high affinity CB[7...

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Detalhes bibliográficos
Main Authors: Moghaddam, Sarvin, Yang, Cheng, Rekharsky, Mikhail, Ko, Young Ho, Kim, Kimoon, Inoue, Yoshihisa, Gilson, Michael K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065999/
https://ncbi.nlm.nih.gov/pubmed/21341773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja109904u
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