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Dietary induction of NQO1 increases the antitumour activity of mitomycin C in human colon tumours in vivo
The bioreductive antitumour agent, mitomycin C (MMC), requires activation by reductive enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1). We used a novel approach to increase MMC efficacy by selectively inducing NQO1 in tumour cells in vivo. CD-1 nude mice were implanted with HCT116 cells, and fe...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2409939/ https://ncbi.nlm.nih.gov/pubmed/15467770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602171 |
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