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Enhanced cytotoxicity of mitomycin C in human tumour cells with inducers of DT-diaphorase
DT-diaphorase is a two-electron reducing enzyme that activates the bioreductive anti-tumour agent, mitomycin C (MMC). Cell lines having elevated levels of DT-diaphorase are generally more sensitive to MMC. We have shown that DT-diaphorase can be induced in human tumour cells by a number of compounds...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2362377/ https://ncbi.nlm.nih.gov/pubmed/10376975 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690489 |
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