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Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents.

DT-diaphorase is a two-electron-reducing enzyme that is an important activator of bioreductive anti-tumour agents, such as mitomycin C (MMC) and EO9, and is inducible by many compounds, including 1,2-dithiole-3-thiones (D3Ts). We showed previously that D3T selectively increased DT-diaphorase activit...

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Detalles Bibliográficos
Main Authors: Doherty, G. P., Leith, M. K., Wang, X., Curphey, T. J., Begleiter, A.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1998
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150177/
https://ncbi.nlm.nih.gov/pubmed/9579829
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