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Enhanced cytotoxicity of mitomycin C in human tumour cells with inducers of DT-diaphorase

DT-diaphorase is a two-electron reducing enzyme that activates the bioreductive anti-tumour agent, mitomycin C (MMC). Cell lines having elevated levels of DT-diaphorase are generally more sensitive to MMC. We have shown that DT-diaphorase can be induced in human tumour cells by a number of compounds...

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Hlavní autoři: Wang, X, Doherty, G P, Leith, M K, Curphey, T J, Begleiter, A
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 1999
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2362377/
https://ncbi.nlm.nih.gov/pubmed/10376975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6690489
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