Dietary induction of NQO1 increases the antitumour activity of mitomycin C in human colon tumours in vivo

The bioreductive antitumour agent, mitomycin C (MMC), requires activation by reductive enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1). We used a novel approach to increase MMC efficacy by selectively inducing NQO1 in tumour cells in vivo. CD-1 nude mice were implanted with HCT116 cells, and fe...

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Bibliografiska uppgifter
Huvudupphovsmän: Begleiter, A, Leith, M K, Thliveris, J A, Digby, T
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2004
Ämnen:
Experimental Therapeutics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409939/
https://ncbi.nlm.nih.gov/pubmed/15467770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602171
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