Liver Receptor Homolog-1 Regulates Bile Acid Homeostasis but Is Not Essential for Feedback Regulation of Bile Acid Synthesis

Liver receptor homolog 1 (LRH-1), an orphan nuclear receptor, is highly expressed in liver and intestine, where it is implicated in the regulation of cholesterol, bile acid, and steroid hormone homeostasis. Among the proposed LRH-1 target genes in liver are those encoding cholesterol 7α-hydroxylase...

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Main Authors: Lee, Youn-Kyoung, Schmidt, Daniel R., Cummins, Carolyn L., Choi, Mihwa, Peng, Li, Zhang, Yuan, Goodwin, Bryan, Hammer, Robert E., Mangelsdorf, David J., Kliewer, Steven A.
Format: Artigo
Jezik:Inglês
Izdano: The Endocrine Society 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409274/
https://ncbi.nlm.nih.gov/pubmed/18323469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2007-0565
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